The Role of Regulatory T-cells in Antitumor Immune Response
نویسندگان
چکیده
منابع مشابه
IFN-gamma controls the generation/activation of CD4+ CD25+ regulatory T cells in antitumor immune response.
Immunization with serological identification of Ags by recombinant expression cloning (SEREX)-defined self-Ags leads to generation/activation of CD4+ CD25+ regulatory T cells with suppressive activities and enhanced expression of Foxp3. This is associated with increased susceptibility to pulmonary metastasis following challenge with syngeneic tumor cells and enhanced development of 3-methylchol...
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and CD8 1 T cells specific for tumor-associated antigens. The role of CD4 1 T helper cells (Th) in this response has been largely attributed to providing regulatory signals required for the priming of major histocompatibility complex class I restricted CD8 1 cytolytic T lymphocytes, which are thought to serve as the dominant effector cell mediating tumor killing. However, analysis of the effect...
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The induction of optimal systemic antitumor immunity involves the priming of both CD4(+) and CD8(+) T cells specific for tumor-associated antigens. The role of CD4(+) T helper cells (Th) in this response has been largely attributed to providing regulatory signals required for the priming of major histocompatibility complex class I restricted CD8(+) cytolytic T lymphocytes, which are thought to ...
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ژورنال
عنوان ژورنال: Klinicka onkologie
سال: 2015
ISSN: 0862-495X,1802-5307
DOI: 10.14735/amko20154s23